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1 / 15 | 2021 4 20 陈梦洁 S0300520100001 010-64814022 12 2021-04-06 2021-04-12 2021-04-19 bsAb Bispecific Antibody / / T TCR T T CD3 CD3 -3% 10% 24% 37% 51% 20-04 20-07 20-10 21-01 21-04 沪深300 医药生物 2 / 15 . 3 / . 4 . 7 “ ” . 8 + “ ” . 9 .11 . 12 . 12 . 13 . 13 1 T . 3 2 “ ” “ ” . 4 3 MHC- TCR . 5 4 / T . 5 5 Blincyto . 6 6 NK ADCC . 6 7 AFM13 . 7 8 AFM13 . 7 9 . 8 10 . 8 11 / . 9 12 AK104 . 9 13 AK104 PD-1 CTLA-4 . 9 14 GEN-1046 . 10 15 ES101 .11 16 RTK .11 17 KN026 . 12 18 VEGF . 13 3 / 15 / T / T T -MHC T TCR T T APC Costimulation TCR T 1 T Cancer Discovery / TIL TIL 4 0 TIL / Altered-excluded altered-Immunosuppressed CD3+ CD8+ 4 / 15 2 Nature / Tumor Immune Escape T CD8+T TCR MHC- - MHC TCR MHC 5 / 15 3 MHC- TCR Nature Reviews T TCR T T T 4 / T lookfordiagnosis T CD3 CD3 CD3 CD3 T T Nature Review Drug Discovery 2019 3 CD3 Blincyto CD19 CD3 6 / 15 Blincyto T TCR CD3 B CD19 T CD19 ALL ALL 5 Blincyto Bispecific Antibodies Design Therapy Perspectives CD3 Removab CD3 EpCAM 2010-2012 332 443 454 2017 Removab Removab Removab T T Fc Blincyto BiTE FC IgG scFv T NK Fc NK FcR Fab ADCC 6 NK ADCC Immunol 7 / 15 AFM13 CD16A CD30 100KD T CD16A NK Fc IgG1 ADCC CD16A 158V 158F 158F IgG1-Fc ADCC 7 AFM13 Affimed AFM13 NK CD30 ADCC ADCP 2021AACR AFM13 / CD30 ORR 100% 4 CR PR 8 AFM13 Affimed T APC Antigen Presenting Cell T T T 8 / 15 9 Cancer Discovery PD-1 CTLA-4 CTLA-4 PD- L 1 LAG-3 TIM-3 TIGIT VISTA OX40 CD28 CD27 GITR ICOS 10 Talks PD-1 CTLA-4 PD-1 CTLA-4 TRAE CheckMate 067 PD-1 3-4 22% CTLA-4 3-4 28% 3-4 9 / 15 59% PD-1 CTLA-4 TIL Tumor Infiltrating lymphocyte TIL TRAE AK104 PD-1 CTLA-4 TIL TIL 11 / 12 AK104 PD-1 CTLA-4 CTLA-4 PD-1 TIL PD-1 CTLA-4 PD-1/CTLA-4 13 AK104 PD-1 CTLA-4 + CD27 CD40 OX40 GITR 4-1BB 10 / 15 4-1BB 4-1BB T 4-1BB T CTL NK 4-1BB 4-1BB BMS Urelumab BMS-663513 4-1BB GEN-1046 PD-L1/4-1BB 2019 6 BioNTech DuoBody PD-L1/4-1BB GEN-1046 / a PD-L1 PD-1/PD-L1 4-1BB 4-1BB 2020 SITC / a GEN-1046 14 GEN-1046 2020 SITC ES101 ES101 PD-L1 4-1BB ES101 PD-L1 T 4-1BB ES101 PD-L1 PD-1/PD-L1 ES101 T 4-1BB ES101 PD-L1 4-1BB 4-1BB T 4-1BB T ES101 PD-L1 PD-L1 4-1BB PD-L1 T 11 / 15 15 ES101 Receptor Tyrosine Kinase RTKs RTKs EGFR PDGFR VEGFR FGFR RTKs 16 RTK TKI TKI 12 / 15 NCCN EGFR EGFR-TKI TKI 612 TKI T790M EGFR c-Met FGFR PI3K AKT HER HER HER KN026 HER2 HER2 D2 D4 KN026 HER2 HER2 HER2 MBS301 HER2 D2 D4 ADCC 17 KN026 2mm VEGF IBI302 VEGF N VEGF VEGF AMD IBI302 C C3b C4b 13 / 15 AMD 18 VEGF TNF- IL-6 TGF- IL-10 IL-13 IL-4 KIH SAR156597 TNF- IL-17A DVD-IG ABT-122 14 / 15 2016 S0300520100001 10485001 12 300 10% 5%10% -5%5% -5% 12 300 5% -5% 5% 5 15 / 15 60 21-23 6 2 1088 20
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