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Executive InsightsRemarkable advances in genomics technologies bring the promise of extraordinary changes in healthcare and some of those changes are arriving now. Whats unfolding are nine trends that we think will shape the life sciences markets in this accelerating genomics revolution. First, some background on how we got here.Impacts of genomics are already enormousThe field of genomics has surpassed expectations over the past three decades due to massive changes in technology that allowed researchers to interrogate larger pieces of the human genome. The modern era of genomics arguably began in the mid-1980s with the development of the polymerase chain reaction (PCR) technique that enabled researchers to characterize the genome at the candidate gene level. In the early 1990s, scientists leveraged semiconductor manufacturing techniques to develop microarrays that enabled large-scale genotyping and gene expression profiling studies. In 2003, at a cost of around $3 billion, the first human genome was completed. Since then, next generation sequencing (NGS) has dramatically decreased in cost, recently breaking the barrier of $1,000 per human genome.These enabling technologies have not only transformed genomics research, but they also opened the door to clinical genomics (i.e., molecular diagnostics see Figure 1). In the clinic, genomic techniques have revolutionized testing across the areas of infectious disease, cancer and inherited disease by enabling measurement of new analytes, improving analytical performance (e.g., sensitivity) and in some cases providing faster turnaround time compared with traditional testing methods.Nine trends that will carry Genomics into 2020 (and beyond)We are only at the beginning of the genomics revolution. What follows are nine key trends and the enabling technologies that Genomics 2020: Research and Clinical Trends to WatchVolume XVIII, Issue 43Genomics 2020: Research and Clinical Trends to Watch was written by Brian Baranick and Alex Vadas, Managing Directors in L.E.K. Consultings Biopharma and Life Sciences practice. Brian and Alex are based in Los Angeles. For more information, please contact lifescienceslek. Figure 1 Genomics research leading to clinical genomicsWW research genomic supplier market* (2016E)WW clinical genomic supplier market* (2016E)USD (billions)0123456USD (billions)012345678ArrayMid-Multiplex*ISHSanger*NGSPCRNote: *Includes instruments and reagents; *Includes Sanger sequencing and hybrid capture; *Includes Nanostring, Luminex, etc.Source: L.E.K. analysiswill carry the genomics revolution through 2020 (see Figure 2 for how genomics trends have led to the establishment of technology innovators).1. Yes, further adoption of NGS. Driven by workflow simplification, continued cost reductions (for both instruments and reagents) and enhanced bioinformatics capabilities, NGS adoption will widen at the high- and low-throughput ends of the research market. There is also broader adoption of NGS-based testing in clinical markets in the areas of oncology, reproductive health and genetics. Against this backdrop, a number of companies are continuing to innovate (e.g., RNA-sequencing, long-read technologies), which will broaden both the research and clinical application sets.2. Moving to single-cell biology. Currently, most genomic analyses suffers from the fact that “average measurements” are taken. In most cases, the sample is lysed, the DNA is extracted and isolated, and analytical measurements are made across different populations (e.g., heterogeneous cells, heterogeneous molecular makeups) in the sample. A number of technology developments may enable researchers to explore biology at the single-cell level, thereby eliminating the heterogeneity issue. Those include: Sample enrichment: Tools exist (e.g., microfluidics, flow cytometry sorting) that make it possible to partition single cells for subsequent molecular analysis. Molecular indexing: Genomic material from individual cells can be uniquely labeled and subsequently pooled for sequencing, enabling researchers to look at gene expression at the individual cell level and compare expression patterns across cell populations, thereby yielding unparalleled insights on cellular heterogeneity. Highly sensitive tools: Highly sensitivity genomic technologies (e.g., NGS, digital PCR) permit researchers to explore genomics at the individual cell level, generating new insights into biological processes ranging from normal development to tumor evolution.3. Emergence of RNA biology. An increasing number of publications are highlighting disconcordance between DNA mutations and downstream changes in RNA and/or protein expression. RNA is potentially a more biologically relevant measurement than a surrogate DNA mutation; despite this fact, adoption of RNA analysis in research and clinical markets has failed to keep pace with DNA analysis. Much of this has to do with the difficulties in handling and interrogating RNA. Enabling tools are emerging that can help propel the field of RNA biology including NGS-based RNA sequencing, which permits researchers to measure the entire transcriptome as well as non-coding RNA, and RNA in situ hybridization (RNA-ISH), which enables single-cell analysis of RNA from cell/tissue samples.Executive InsightsPage 2 L.E.K. Consulting / Executive Insights, Volume XVIII, Issue 43 INSIGHTSWORKnullGenomics Trends* Key Technology InnovatorsNGS Instruments IlluminaPacBioQiagenThermo Fisher (Ion Torrent)Sample preparation10x GenomicsAgilentFluidigmNEBRocheInformatics Seven BridgesDNAnexusGenospaceN-of-OneOmiciaSingle Cell Becton DickinsonFluidigmWaferGenRNA Biology Bio-Techne (Advanced Cell Diagnostics)HTG MolecularMolecular StethoscopeResearch Tools Epic SciencesClinical Tests BioceptCynvenioGuardant HealthNateraPersonal Genome DiagnosticsLabCorp (Sequenom)TrovageneMendelian Genetic Testing CounsylGood Start GeneticsPoint-of-Care Testing Abbott (Alere)CepheidRocheFigure 2Genomics trends and key innovatorsNote: *Trends 7 9 are excluded as they are not driven by technology innovation. Source: L.E.K. analysis4. Emergence of the “molecular stethoscope.” The discovery of cell-free DNA (cfDNA) in circulation has opened the door to what is popularly referred to as the “molecular stethoscope.” The first clinical application of cfDNA was noninvasive prenatal testing (NIPT), which leverages the ability to detect and interrogate fetal DNA in maternal blood, thus providing a test for fetal chromosomal abnormalities that does not require amniocentesis. Clinical applications of cfDNA extend to cancer (early detection, therapy monitoring, disease recurrence monitoring), pathogen detection for infectious disease and transplant monitoring. Capturing and analyzing rare cell populations are an extension to the molecular stethoscope concept and take advantage of the single-cell genomics approaches discussed above.5. Mendelian genetic testing. Clinical genomics will vastly improve the entire reproductive health diagnostic paradigm. Genetic testing will begin with carrier screening of mother and father in order to assess more than 250 hereditary diseases. It will extend to in vitro fertilization (IVF) with embryos being examined for inheritance of disease. Additionally, genetic testing will occur inutero in mothers, analyzing for inherited diseases (e.g., microdeletions). Trio testing, where mother, father and child are tested, could provide even more powerful information on true inheritance patterns and disease predispositions. Furthermore, population-level genomic data may also yield insights not only into disease, but also into important areas including fertility, resilience and longevity.6. Testing moves closer to the patient. Technology advances have automated workflows, decreased instrument footprints, reduced turnaround time and simplified test result interpretation. These upgraded capabilities have made it possible for clinical genomic technologies to “decentralize” outside the traditional high-volume central reference laboratories into community hospital labs and physician offices (point of care). Continued innovation (e.g., analysis directly from crude samples) will further broaden adoption at the point of care, leading to potentially significant improvements in outcomes as well as patient management economics. 7. Genotype meets phenotype. Bioinformatics will unlock genomics across research and clinical markets, but will require integration of siloed datasets. Large scale efforts such as the 1000 Genomes Project and The Cancer Genome Atlas have generated volumes of genomic data, but these datasets often lack any phenotype or outcomes data. Conversely, EMRs often contain detailed longitudinal patient outcomes data, but here again, data is siloed within a given provider institution. Several efforts (e.g., ASCO CancerLinQ) are underway to link genotype with phenotype in an effort to derive clinical significance from genetic variation.8. Scaling the research experiment. As we discover more genomic biomarkers and unlock genetic diversity, the associated prevalence of these biomarkers will inevitably decrease. To explain the vast genomic differences across populations, researchers will need to conduct experiments at an unprecedented scale. The aforementioned examples (TCGA, 1000 Genomes) are moving into bigger scale studies, but we expect even larger and more coordinated research will be needed (e.g., Million Veteran Program).9. Clinical trial baskets. With the continued unlocking of genetic diversity, we can expect development of more and more targeted therapies aimed at narrow patient populations harboring specific (and increasingly rare) genomic biomarkers. As this unfolds, biopharmaceutical companies will face significant challenges in identifying and enrolling patients for a given drugs clinical trial. Early coordinated efforts (e.g., Lung Cancer Master Protocol) to address the patient enrollment problem are already underway, but we believe these types of efforts are likely to become more common and make a meaningful impact on drug development. These trends have the potential to create sizable commercial opportunities for in vitro diagnostic (IVD) companies, reference laboratories, life science tools companies and bioinformatics vendors. We encourage these industry participants to develop strategies to help capitalize on the continued genomics revolution.Executive InsightsPage 3 L.E.K. Consulting / Executive Insights, Volume XVIII, Issue 43Executive InsightsPage 4 L.E.K. Consulting / Executive Insights, Volume XVIII, Issue 43L.E.K. Consulting is a global management consulting firm that uses deep industry expertise and rigorous analysis to help business leaders achieve practical results with real impact. We are uncompromising in our approach to helping clients consistently make better decisions, deliver improved business performance and create greater shareholder returns. The firm advises and supports global companies that are leaders in their industries including the largest private and public sector organizations, private equity firms and emerging entrepreneurial businesses. Founded more than 30 years ago, L.E.K. employs more than 1,200 professionals across the Americas, Asia-Pacific and Europe. For more information, go to lek.L.E.K. Consulting is a registered trademark of L.E.K. Consulting LLC. All other products and brands mentioned in this document are properties of their respective owners. 2016 L.E.K. Consulting LLCBrian Baranick is a Managing Director and Partner in L.E.K. Consultings Los Angeles office. He joined L.E.K.s Biopharma and Life Sciences practice in 2007 and has supported clients across many sectors, including biopharmaceuticals, life science tools, diagnostics and personalized medicine. Brian also has experience across a broad range of therapeutic area and technology segments. Alexander Vadas, Ph.D., is a Managing Director and Partner in L.E.K. Consultings Biopharmaceuticals & Life Sciences practice. He joined L.E.K. in 2000 and focuses on diagnostics, research tools and personalized medicine. Within those areas, Dr. Vadas has worked with a range of established and emerging clients in the areas of corporate strategy, product strategy and planning and transaction support.About the Authors
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